Th-mycn transgenic mice
WebApr 9, 2024 · Capitalizing on this, many mouse models of cancer have been developed using tissue-specific transgenic overexpression of MYC genes, providing insight into the role of MYC in cancer. Such models include the Eμ-MYC model of B cell leukemia/lymphoma, the TH - MYCN model of neuroblastoma, the Lo-MYC and Hi-MYC models of prostate cancer, … WebApr 1, 2013 · Image analysis of TH-MYCN mice undergoing chemotherapy treatment against neuroblastoma provided information on drug-induced alterations in tumor metabolic …
Th-mycn transgenic mice
Did you know?
WebJan 27, 2024 · 2.1 GEMMs of MYCN-amplified high-risk neuroblastoma. The Th-MYCN transgenic mouse model, developed in 1997 [], is the most widely used and best … WebJul 10, 2012 · Purpose TH-MYCN transgenic mice represent a valuable preclinical model of neuroblastoma. Current methods to study tumor progression in these mice are inaccurate or invasive, limiting the potential of this murine model. The aim of our study was to assess the potential of small animal positron emission tomography (SA-PET) to study neuroblastoma …
WebMar 15, 2014 · The 9464D TH-MYCN model (referred to as 9464D model hereafter) generated by Weiss et al. is a transgenic model in which human MYCN is overexpressed … WebJun 1, 1997 · TLDR. The rat tyrosine hydroxylase promotor is used to overexpress MYCN in the neural crest of transgenic mice, resulting in a mouse model for neuroblastoma, and genome-wide analysis in tumors from these animals suggest that genetic mutations on chromosomes 1, 3, and 10 cooperate in the pathogenesis of Neuroblastoma. 46.
WebDec 20, 2024 · To address some of the limitations of the TH-MYCN model, a mouse with Cre inducible MYCN expression (LSL-MYCN;Dbh-iCre) was created [].This model has a better … WebThe TH-MYCN transgenic mouse is a promising in vivo model for testing immunotherapy compounds and combination therapy in a preclinical setting. Show less See publication. …
WebJan 31, 2024 · The TH-MYCN transgenic mouse is now a well-established model of neuroblastoma, and a panel of homozygous and hemizygous TH-MYCN cell lines have …
WebFeb 14, 2012 · The TH-MYCN transgenic mouse model of neuroblastoma, which has the expression of the human MYCN oncogene targeted to mouse neuroectodermal cells via the rat tyrosine hydroxylase promoter, has been previously described . When medium palpable tumors (∼1 cm 2 ... definition of thicketWebSep 10, 2024 · A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma Int. J. Canc. , 134 ( 2014 ) , pp. 1335 - … definition of thickly settledWebFeb 3, 2024 · Overexpression of N-MYC initiates tumorigenesis by preventing the normal physiological process of neural crest cell death in TH-MYCN transgenic mice in which … female horror iconsWebMouse caspase-8 gene was deleted in neural crest lineage cells by crossing a Th-Cre transgenic mouse with a caspase-8 conditional knockout mouse. This mouse was then … female horses in heatWebSep 4, 2009 · The origin of TH-MYCN transgenic mice in our facility is derived from NCI. Thus, the TH-MYCN transgenic mice we used in this study are the same lineage … definition of thickened endometriumWebMYCN, Th-MYCN, TH-NMYC: Transgene: Tg(Th-MYCN)41Waw Location: unknown Alliance: Tg(Th-MYCN)41Waw page ... Mice carrying this transgene on a 129X1/SvJ background … female horse feeding its babyWebThe widely used transgenic model, the Th-MYCN mouse, exhibits limited metastasis to this site. Here, we establish the first genetic … female horse in french