Speck formation
WebAug 15, 2024 · Speck formation required the ASC Y152 phosphorylation site that is conserved between zebrafish, mouse (Y144), and human (Y146), and that was previously reported to control ASC speck assembly in murine cells (Hara et al., 2013). Both studies support a model in which ASC phosphorylation at this site is a regulatory switch, … WebOct 21, 2024 · Speck formation is rapid causing a concomitant drop in cytosolic ASC concentration, approximately 200-fold, to submicromolar concentrations within 100 s ( 2 ), …
Speck formation
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WebOct 26, 2024 · To investigate whether lack of ASC speck formation was attributable to the absence of gene and protein expression from the ALR family, we generated a human AIM2-mCitrine fusion construct cloned into a mammalian expression vector and rescued the gene in Pteropus alecto kidney-derived (PaKiS) immortalized cells ( 34 ). WebThe objective of Speck Lab is to discover new mechanisms in initiation of DNA replication and to understand the function of replication factors in hetero-chromatin formation and epigenetic memory. This knowledge is used to understand disease associated process and in order to develop novel DNA replication inhibitors.
WebDefine speck. speck synonyms, speck pronunciation, speck translation, English dictionary definition of speck. n. 1. A small spot, mark, or discoloration. 2. A tiny amount; a bit: not a … Webspeck: 1 n a very small spot “the plane was just a speck in the sky” Synonyms: pinpoint Type of: dapple , fleck , maculation , patch , speckle , spot a small contrasting part of something …
WebOct 6, 2024 · In addition, ASC speck formation was also impaired in LPS-primed U937 expressing NLRP3 S806D treated with nigericin (Fig. 2d). S806 substitutions impaired IL … WebDec 1, 2013 · TL;DR: The results suggest that phosphorylated of ASC controls inflammasome activity through the formation of ASC specks, and that Syk and Jnk are upstream of ASC phosphorylation. Abstract: The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling …
WebOct 13, 2015 · These data show that mutations in the type I interface can prevent ASC speck formation and inflammasome signaling during activation of the three best-studied inflammasome receptors, NLRP3, AIM2, and NLRC4. The disruption of filament formation upon mutation of lysine 21 or 26 to alanine confirms the importance of the precise …
WebDownload scientific diagram Characteristics of microglial ASC-speck formation in mice and humans a, b, Immunohistochemistry of the microglial marker CD11b and ASC in sections derived from brains ... ceramic ball ashtrayWebJul 12, 2016 · Speck formation is the hallmark of inflammasome activation and can be studied in vitro using fluorescent ASC-overexpressing macrophage cell lines. However, the lack of an in vivo tool for studying ASC speck formation has limited the understanding of inflammasome activation under conditions of inflammation, especially in the context of … ceramic hamster toysWebSep 14, 2024 · ASC Speck formation. One of the possible projects is understanding how protein sequence variants impact inflammasome formation. There are multiple possible … ceramic cookware chafer buffetWebAug 10, 2015 · The ASC speck formation is not affected by proteasomal inhibition, yet co-aggregation of ovalbumin is favored by MG132. This result indicates that the ASC speck formation and co-aggregation of ovalbumin on the ASC speck are two different processes. ceramic light switch plateceramic coating on a vehicleWebJan 4, 2024 · Fig. 4: IL-10-induced inhibition of IL-1β production, caspase-1 activation, and ASC speck formation is reversed in AIM-deficient BMDM. a, b BMDM from WT and AIM−/− mice were treated with LPS (100... ceramic clay roof tilesWebEMILIE SPECK BERNIER’S Post EMILIE SPECK BERNIER Ressources Humaines / Chargée de formation 4y ceramic painting near norwood ma