Paclitaxel resistance tubulin
WebDec 1, 2008 · Abstract. Aberrant expression of β-tubulin isotypes is frequently described in tumor tissues and tubulin-binding agent (TBA)–resistant cell lines. There is limited … WebMar 19, 2024 · Microtubules are tiny, very rigid, cylindrical, hollow tubes with a diameter of approximately 25 nm, composed of the two globular proteins, α- and β-tubulin with a total molecular weight of 50 kDa each [Figure 1]. In humans, eight isoforms of each α- and β-tubulin have been identified[2].
Paclitaxel resistance tubulin
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Web58 rows · One study found that paclitaxel pre-treatment of their cisplatin-resistant cell lines increased the accumulation of cisplatin and was associated with tubulin alterations. 79 If … WebApr 17, 2001 · The chemotherapeutic drug Taxol is known to interact within a specific site on β-tubulin. Although the general location of the site has been defined by photoaffinity labeling and electron crystallography, the original data were insufficient to make an absolute determination of the bound conformation.
WebJun 13, 2024 · Paclitaxel (trade name Taxol) is a tricyclic diterpenoid compound naturally produced in the bark and needles of Taxus brevifolia.Its molecular formula is C 47 H 51 NO 14, and its chemical structure is shown in Fig. 1.Because of its unique anticancer mechanism, it is already one of the most successful and widely used natural anticancer … WebThe proteins with ratio values of more than 1.2-fold or less than 0.83-fold (P<0.05) were considered as differentially expressed proteins (DEPs). In paclitaxel group compared with control, 499 DEPs were identified, 281 (56.3%) of which were up regulated and 218 (43.7%) of which were down-regulated.
WebApr 6, 2024 · We showed that paclitaxel-resistant H460 lung cancer cells, generated by a stepwise increase in paclitaxel, exhibited markedly increased tubulin acetylation and consequently acquired paclitaxel ... WebMechanisms of the resistance to paclitaxel are complex as indicated by cumulative studies, which include alterations in microtubule dynamics, altered expression of β-tubulin isotypes, and also deregulated signaling pathways. 21–24 In our own serial studies, we have demonstrated that activation of PI-3K/Akt signaling plays a critical role in ...
WebIt has been approximately ten years since the Food and Drug Administration (FDA) approved paclitaxel for the treatment of platinum resistant epithelial ovarian carcinoma. …
WebMay 9, 2003 · Taxol (paclitaxel) is a mitotic inhibitor that has been successfully used in the treatment of breast, ovarian, and lung carcinomas. The powerful antitumor activity of Taxol results from its ability to promote the assembly and stabilization of microtubules ( 1 ). domenica szramaWebNov 21, 2024 · paclitaxel must be given slowly, and the infusion can take 3 to 24 hours to complete. Paclitaxel is usually given once every 2 to 3 weeks. Follow your doctor's … pv tribune\\u0027sWebfrom parental and Taxol/epothilone-resistant human cancer cell lines. This method allows the direct determination of tubulin isotype composition, including post-translational modifications and mutations occurring throughout the entire protein. Four major isotypes, âI-,âIVb-, KR1-, andR6-tubulin, were detected in two human carcinoma cell lines ... domenica su tv8WebThe cellular uptake, intracellular nanoparticle trajectory, and subsequent cellular events were evaluated after treatment with various PLGA nanocomplexes in human lung cancer … pv tribe\\u0027sWebApr 14, 2024 · The role of miR-18a and increased autophagy is corroborated by another study that shows how paclitaxel-resistant MDAMB231 cells have higher basal levels of both miR-18a ... autophagy in breast cancer cells, it also leads to hyperacetylation of tubulin, thus hindering the fusion of lysosomes and autophagosomes, which results in … domenica tiromancino karaokeWebMay 18, 2024 · The single channel tubulin and DAPI images that correspond to Figure 1, A–F, are shown in A and B. Loss of DTE in docetaxel-resistant PCa xenografts. To decipher in vivo mechanisms of … domenica svadbaWebApr 6, 2024 · Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization Tubulin acetylation enhances lung cancer … pv trojans