2024 Klf14 gene polymorphism

Klf14 gene polymorphism

Author: qgey

August undefined, 2024

WebNew, quick, and inexpensive methods for genotyping KLF14 gene polymorphism through Tetra Primer ARMS-PCR were developed in the present investigation. Sin-gle nucleotide polymorphism (SNP) genotyping needs to be attempted to establish association between the identified SNP with metabolic trait for identification of mo- WebReplication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations

Clinical Implications of Krüpple-like Transcription Factor …

WebMay 4, 2007 · Thus, KLF14 is the ninth imprinted retrotransposed gene identified to date and the first protein-coding maternally expressed retrotransposed gene identified in mouse, … WebAug 16, 2024 · This study was aimed to detect KLF14 gene polymorphism in Iraqi type 2 diabetes mellitus patients (T2DM) to found the correlation between the SNP (rs972283) polymorphism in KLF14 gene and lipid metabolism and impact on the incidence of type 2 diabetes mellitus (T2DM). The result show high Significant difference comprehensive integrated care phoenix az

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WebGene polymorphism studies have revealed that multiple SNPs are implicated in the development of T2DM. Therefore, genetic risk factors of T2DM need to be explored for … WebMay 4, 2007 · We then calculated π values at nonsynonymous and synonymous SNP sites separately and determined that KLF14 had a higher π value than 779 of the 827 genes (94.2%) within each of these sets, revealing that the gene's significant enrichment in SNPs is due to elevated numbers of both synonymous and nonsynonymous polymorphisms. WebNov 9, 2024 · KLF14 was recently identified as an activator protein and novel regulator of lipid signaling by binding to GC-rich regions in the sphingosine kinase 1 ( Sk1) promoter and regulating fibroblast growth factor 2 (FGF2)-stimulated Sk1 promoter activity ( 17 ). echo dot at best buy

The KLF14 Variant is Associated with Type 2 Diabetes …

The Association between the KLF14 rs4731702 SNP and the Lipid …

WebApr 6, 2024 · In summary, our study found polymorphic variations in transcription activator KLF14 and miRNAs 27a and 196a genes as functional polymorphisms, which are … WebKLF14在刀豆蛋白A ... polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community … echo dot at tescoWebGenetic polymorphisms that have impacts on important proteins that participate in glucose metabolism and insulin secretion may also affect susceptibility to T2DM. 5 Genome-wide … comprehensive interest schedule manual pdf

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Klf14 gene polymorphism

WebJan 29, 2024 · The severity of the symptoms associated with COVID-19 is highly variable, and has been associated with circulating amino acids as a group of analytes in metabolomic studies. However, for each individual amino acid, there are discordant results among studies. The aims of the present study were: (i) to investigate the association between … WebKLF14 has been used as an epigenetic biomarker for the estimation of chronological age due to the presence of different age-related CpG sites on genes that become methylated with age. Different...

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WebMar 29, 2024 · KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element … WebOct 11, 2012 · KCNJ11 E23K gene polymorphism is located in the 1st exon and formed by missense mutation of the 23rd codon. The substitution mutation of adenine (A base) for guanine (G base) in the 23rd codon replaces glutamine (E) with lysine (K) in the corresponding amino acid sequence.

WebApr 6, 2024 · Clinical Implications of Krüpple-like Transcription Factor KLF-14 and Certain Micro-RNA (miR-27a, miR-196a2, miR-423) Gene Variations as a Risk Factor in the Genetic … WebJan 3, 2024 · KLF14, an intronless gene (1479 bp length) with two CpG Islands, is located at 7q32.3, telomeric to TSGA13 (Testis Specific 13 gene) (Parker-Katiraee et al. 2007 ). It is …

WebJan 29, 2024 · KLF14 is a master trans-regulatory gene, which is involved in the regulation of several biological processes and cellular pathways. KLF14 regulates several important …

WebKLF14 has been used as an epigenetic biomarker for the estimation of chronological age due to the presence of different age-related CpG sites on genes that become methylated with age. Different...

WebMar 9, 2024 · Civelek and his collaborators found that the KLF14 gene is a key regulator of how the female body uses lipids (fats). The gene makes a protein that plays a critical in how fat cells form,... comprehensive internal medicine wooster ohWebKLF14 is a member of a large family of zinc-finger transcription factors that has been widely studied in embryogenesis, cell proliferation, differentiation, and development. The 18 KLFs described in mammals possess highly conserved cysteine and histidine zinc fingers, critical for recognition and binding to CACCC or CGCCC DNA motifs [ 8] . echo dot at walmartWebKLF14. The transcription factor, KLF14, is located on chromosome 7q32.3. Variations in this gene are associated with high-density lipoprotein (HDL)-cholesterol and T2DM. 62,63 A previous study showed that KLF14 is involved in metabolism as a transcriptional activator as it regulates the gene networks that participate in lipid metabolism. 64 KLF14 gene is … comprehensive insurance solutions las vegasWebMay 9, 2024 · The association between KLF14 gene polymorphism and T2DM was studied in two models of inheritance, i.e., dominant and recessive. In these two models there were no significant associations between KLF14 rs972283 polymorphism and T2DM. echo dot as speakerWebDec 16, 2016 · Finally, genotyping of the rs4731702 (C/T) polymorphism of the KLF14 gene can be of high predictive and interventional value of cardiovascular complications in our, and probably other, populations which have a high prevalence of T2DM. Acknowledgements comprehensive integrated care foot and ankleWebSep 11, 2024 · The KLF14 G-containing genotypes exerted a significant effect on lowering HDL-c ( P = .026) and on elevating LDL-c ( P = .045) and cholesterol level ( P = .042) in the control group. The FTO “CC” genotype showed a significant effect on raising HbA1c level in the patients ( P = .007). comprehensive integrated border managementWebThe corresponding Klf14 mouse gene is known as Sp6. ... KLF14 appears to be a master regulator of gene expression in adipose tissue. Protein structure. Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C 2 H 2 type. In the human, they are at amino acids 195 ... comprehensive interventional pain management