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Grwd1 and p21

WebGRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that GRWD1 expression levels are inversely correlated with the expression levels of some p53-target genes. Interestingly, high GRWD1 expression in combination with low expression levels of some … WebJan 1, 2024 · Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer. ...

(PDF) GRWD1 affects the proliferation, apoptosis, invasion …

WebAug 20, 2016 · Request PDF Nucleosome assembly and disassembly activity of GRWD1, a novel Cdt1-binding protein that promotes pre-replication complex formation GRWD1 was previously identified as a novel Cdt1 ... WebGRWD1. Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known … dr robert cusick https://catesconsulting.net

GRWD1 protein expression summary - The Human Protein Atlas

WebFeb 15, 2024 · GRWD1 is a member of the WD repeat protein family that is over-expressed in various cancer cell lines and associated with poor prognosis in patients with cancer. However, its biological function and mechanism in non-small cell lung cancer (NSCLC) remain unclear. In this study, we aimed to elucidate the role of GRWD1 in NSCLC. WebJan 1, 2024 · GRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that … WebGRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that GRWD1 expression … collingtree houses for sale

GRWD1 affects the proliferation, apoptosis, invasion and …

Category:GRWD1 regulates ribosomal protein L23 levels via the ubiquitin ...

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Grwd1 and p21

GRWD1 Gene - GeneCards GRWD1 Protein GRWD1 Antibody

WebMay 30, 2024 · GRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we … WebFeb 15, 2024 · GRWD1 can competitively bind RPL11 and promote the recovery of MDM2 ubiquitin ligase activity, thereby negatively regulating p53 [18]. GRWD1 is over …

Grwd1 and p21

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WebJun 1, 2001 · Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6 (PubMed:25990725). Binds to histone H2A-H2B and H3-H4 complexes (PubMed:25990725). 2 publications. Protein-protein interaction databases. BioGRID. … WebThe expression of downstream genes of the Notch signaling pathway Hes1, Hes5, Hey1, Hey2, p21, c-Myc, cyclin D1, human epidermal growth factor 2 receptor and NF-κB were …

WebAug 3, 2024 · GRWD1 also belongs to the family of DNA damage-binding protein 1 (DDB1)-interacting WD40 proteins, which function as candidate substrate receptors for Cul4–DDB1 ubiquitin ligases (note that there are Cul4a and Cul4b forms of Cul4 in mammals) (He et al., 2006; Higa et al., 2006).For example, Cdt2, a Cul4–DDB1-interacting WD40 protein, is a … WebFeb 16, 2024 · GRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that GRWD1 expression levels are inversely ...

WebMay 30, 2024 · GRWD1 knockdown suppressed TNBC cell proliferation, invasion and migration and promoted TNBC cell apoptosis. ... Hes5, Hey1, Hey2, p21, c-Myc, cyclin D1, human epidermal growth factor 2 receptor and NF-κB were all suppressed after siRNA-GRWD1 transfection. However, Notch1 overexpression reversed the effect of GRWD1 … WebJul 1, 2005 · GRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that GRWD1 expression levels are inversely ...

WebGRWD1 is a novel negative regulator of p53 and a potential oncogene, and its effects are mediated by the N‐terminal region of GRWD1, including the acidic domain. The ribosomal protein L11 (RPL11) binds and inhibits the MDM2 ubiquitin ligase, thereby promoting p53 stability. Thus, RPL11 acts as a tumor suppressor. Here, we show that GRWD1 …

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 collingtree park care home cqcWebGRWD1 INFORMATION. Proteini. Full gene name according to HGNC. Glutamate rich WD repeat containing 1. Gene namei. Official gene symbol, which is typically a short form of … collingtree primary schoolWebGRWD1 acts as a tumor-promoting factor by downregulating p53 (also known as TP53) via the RPL11-MDM2-p53 axis. Here, we identified GRWD1- interacting proteins using a proteomics approach and showed that GRWD1 interacts with various proteins involved in transcription, translation, DNA replication and repair, chromatin organization, and … dr robert cushingWebthe cyclin-dependent kinase inhibitor p21waf1 and several pro-apoptotic factors [3]. Nucleolar stress, also referred to as ribosomal stress, is one of ... p21 024812 PUMA … dr robert c wangWebNov 17, 2016 · The ribosomal protein L11 (RPL11) binds and inhibits the MDM2 ubiquitin ligase, thereby promoting p53 stability. Thus, RPL11 … dr robert cyrus hair lossWebMar 21, 2024 · GeneCards Summary for GRWD1 Gene. GRWD1 (Glutamate Rich WD Repeat Containing 1) is a Protein Coding gene. Diseases associated with GRWD1 … dr robert c woods lebanon tnWebGRWD1 INFORMATION. Proteini. Full gene name according to HGNC. Glutamate rich WD repeat containing 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. GRWD1 (GRWD, RRB1, WDR28) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). dr robert daley orthopedic surgeon