Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through … See more There are several key differences between naive B cells and GC B cells. Naive B cells do not undergo lots of cell division. On the other hand, B cells in GC B cells tend to divide rapidly and frequently, and they can have cell cycles as … See more There are two distinct regions of the germinal center: the light zone (LZ) and the dark zone (DZ). These two zones are formed from pre-GC B cells that proliferate and polarize seven days following immunization. GC B cells alternate between the dark … See more There are T helper cells in the follicles of the lymph nodes called T follicular helper cells that promote germinal center formation and the differentiation of GC B cells into plasma cells and memory B cells. T follicular helper cells mediate the germinal center … See more The morphology of GCs is very specific and shows properties which are characteristic for different stages of the reaction. • In an early state of the reaction a network of FDCs is fully filled with proliferating B cells. • Later at day 4 of the reaction, GCs show a separation … See more Germinal centers are initiated in the B cell follicle of the lymph node. Following activation of naive B cells in the lymph node follicles, the B … See more 1. Within lymph nodes, mature peripheral B cells known as follicular (Fo) B cells acquire antigen from FDCs and in turn present it to cognate CD4+ TFH cells at the border that demarcates the interfollicular T cell area and B cell zone (also known as lymphoid follicles). See more Following positive selection, there are three possible fates for B cells undergoing the germinal center reaction: become a plasma cell, … See more http://lifesci.dls.rutgers.edu/~babiarz/lympho.htm

Anatomy, Lymph Nodes - StatPearls - NCBI Bookshelf

WebA germinal center in the center of the nodule is the site for B cell proliferation and development. Lymph flows through a node in one direction only. It enters through afferent lymphatic vessels, passes through sinuses (subscapular, trabecular, medullary) that contain lymphocytes and macrophages which filter the lymph to remove damaged cells ... WebNon-encapsulated lymphoid tissue This consists primarily of lymphatic nodules, which are sites of lymphocyte (B-cells) proliferation/activation. The basic structure of a lymphatic nodule is described as a germinal center, where B-lymphocytes have activated and increased in size, surrounded by small, オーディオケーブル おすすめ

Mantle zone - Wikipedia

WebLymphatic nodules with or without germinal centers and with prominent eccentric central arterioles (called “central arteries) may be observed randomly distributed throughout the splenic pulp. These nodules together with areas of dense lymphatic tissue surrounding central arterioles, called the periarterial lymphatic sheaths (PALS), comprise ... Webgerminal center of lymphoid nodule cortex of fetal thymus lobe of fetal thymus lobule of fetal thymus medulla of fetal thymus septum of fetal thymus cortex of fetal thymus lobule of fetal thymus medulla of fetal thymus septum of fetal thymus capsule of spleen germinal center of white pulp spleen red pulp trabecula of spleen white pulp of spleen オーディオケーブルとは